COLLOQUIUM 638
Cellular Mechanobiology and Morphogenesis

21 August — 24 August 2023, Sirmione, Italy

Scientific program

Monday Aug. 21

Opening

Institutional welcoming by Alberto and Eoin

19:00

Carrozza, M. – Municipality of Sirmione

Castelli, F.  – Rector of the University of Brescia

Wine and cheese welcoming

Tuesday Aug. 22

Session 1

Nuclear Mechanobiology

Char: M. Bacca

9:00

9:30

Shenoy, V., How do Forces From the Cell’s Environment Affect DNA Organization?

9:30

10:00

Roca-Cusachs, P., Controlling nuclear mechanics from the extracellular matrix

Coffee break

Session 2

Morphogenesis

Chair: A. Gizzi

10:30

11:00

Garcia-Aznar, JM., Unraveling the morphogenetic pattern of cystic spheroids: an AI-guided physics-based approach

11:00

11:30

Deshpande, V., The role of geometry and boundary conditions in cell organisation in tissue morphogenesis

11:30

12:00

Rangamani, P., Multiscale modeling of lipid bilayers for mitochondrial membrane mechanics.

12:00

12:30

Saif, T., Disorder to order transition in multicellular systems through dynamic nonlinear elastic interactions

Lunch break


Session 3

Mechanobiology of vascular systems

Chair: V. Vogel

14:00

14:30

Loerakker, S., Computational approaches to analyze and predict cell-mediated cardiovascular growth and remodeling

14:30

15:00

Conte, V., The border zone in myocardial infarction: the mechanobiological perspective of cells

15:00

15:30

Schön, I., Mechanobiology of platelet-extracellular matrix interactions during thrombus formation

15:30

16:00

Ristori, T., Multiscale modelling of the spatiotemporal dynamics of angiogenesis in regenerative medicine

Coffee break

Session 4

Active contractility

Chair: V. Deshpande

16:30

17:00

McGarry, P., Modelling active contractility in cells and tissue

17:00

17:30

Nardinocchi, P., Self-contractile biopolymer gels: a continuum mechanics perspective

17:30

18:00

Smith, M., Tensional homeostasis: role of signaling and contractile machinery in suppression of mechanical extremes


Wednesday Aug. 23

Session 5

Mechanobiology of cancer

Chair: V. Shenoy

9:00

9:30

Gräter, F., Protein mechanoradicals: how tissues turn mechanical into oxidative stress

9:30

10:00

McNamara, L., Osteocyte mechanobiology and bone disease: multicellular models to study bone loss during estrogen deficiency and bone metastases

10:00

10:30

McEvoy, E., Mechanobiology of stress-dependent cell and tumour growth

Coffee break

Session 6

Cellular Motility

Chair: P. McGarry

11:00

11:30

Doyle, A., Cell mechanics and motility in 3D microenvironments

11:30

12:00

Madzvamuse, A., Unravelling mechano-biochemical models for 2- and 3-D single cell migration

12:00

12:30

Salvadori, A., Actin-based motility unveiled: from bacteria to cells

Lunch break

Session 7a

Fluidics and Organs on a chip

Chair: A. Gizzi

14:00

14:30

Occhetta, P., BiomimX , Beating organs-on-chip as innovative tools for diseases modelling and advanced therapies evaluation

14:30

15:00

Vassalli, M., Fluidic Force Microscopy to study Cellular Mechanosensing

Session 7b

Extracellular Matrix

Chair: P. Roca-Cusachs

15:00

15:30

Genin, G., Cell-matrix feedback and the development of polarity

15:30

16:00

Vogel, V., Bridging Length Scales: Mechano-Chemical Switching of Extracellular Matrix Fibers

16:00

16:30

Gizzi, A., Growth and remodeling in distributed fiber-reinforced materials

16:30

17:00

Pathak, A., Environmental memory and cell invasion through fibrous microenvironments

18:30

23:00

Poster session and social dinner

Podere Selva Capuzza, Desenzano del Garda

Thursday August 24

Session 8

Experimental and Theoretical Mechanobiology, 1.

Chair: E. McEvoy

9:00

9:30

Bacca, M., Energetics of Diffusion-mediated Processes in Biological Systems: Virus Replication & Cytoskeletal Contraction

9:30

10:00

Kaul, H., Synergy between mechanics and biochemical signalling hinges on cellular energetics

10:00

10:30

Klotzsch, E., Lymphocyte mechano-stimulation for adoptive immunotherapies

Coffee break

Session 9

Experimental and Theoretical Mechanobiology, 2

Chair: A. Doyle

11:00

11:30

Jungmann, R., Localizomics: towards spatial omics using DNA-based super-resolution microscopy

11:30

12:00

Alvarado, J., Connecting active “hardware” to biological “software”

12:00

12:30

Cheng, L., Experimental and modelling techniques for quantifying the electro-mechanical activity in the gut

Lunch break

Session 11

Multicellular systems

Chair: A. Salvadori

14:00

14:30

Marino, M., Phase-field modeling of cell motility in biodegradable hydrogel scaffolds

14:30

15:00

Scita, G., Tissue fluidification in pathophysiology

15:00

15:30

Arroyo, M., A mechano-biological feedback between cancer organoids and the ECM initiates and sustains collective invasion

Closing by Alessio and Mattia